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妻子的死让警探艾德里安（托尼·夏尔赫布 Tony Shalhoub 饰）的生活跌落到了谷底，不久之后，常常陷入悲痛之中的艾德里安患上了强迫症。强迫症令艾德里安在警局里无处容身，很快，他便丢掉了工作，成为了无业游民。 为了生存，艾德里安必须赚钱，就这样，一家私人侦探所成立了。艾德里安雇佣了护士莎罗纳（Bitty Schram 饰）为他打理日常生活，自己则靠着出色的逻辑推理能力和过目不忘的神奇本领解决了一件又一件离奇案件。之后，艾德里安结识了名为娜塔莉（特蕾勒·霍华德 Traylor Howard 饰）的单身母亲，两人之间十分投缘。随着时间的推移，丧妻之痛由浓转淡，但妻子被害一案的前因后果却依然深藏在迷雾之中，艾德里安能够依靠自己的力量破解此案揭开心结吗？
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Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.
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Freeform宣布预订Lonely Island创作的喜剧《一起单身的日子 Alone Together》，Esther Povitsky和Benji Afalo将担任主演，同时也担任编剧和制作人。《一起单身的日子》描述两个来自不同家庭背景，被社会忽视的年轻人Esther 及Benji，他们想融入洛杉矶这个虚荣且多种文化交缠的社会。庆幸的是，两人因此产生了柏拉图式的友谊。
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取材于著名的敦煌壁画。 在唐代的河西走廊，飓风骤起，将波斯商人伊努思带领的商队卷入了风沙之中，伊努思被埋在沙堆里。中国画工神笔张和女儿英娘，无意中发现了伊努思，及时救了他。 神笔张父女与伊努思告别后，不幸为盗所劫英娘被匪首窦虎劫走。英娘被迫学艺，在皮鞭和鼓乐声中长成了一个出色的歌舞伎艺人。五年后，窦虎带他的百戏班子来到敦煌市集，英娘含悲起舞，博得了众人的喝采，也引起了掌管市集贸易的官吏市令的邪念。这时，神笔张寻女也来到市集，终于与女儿英娘相遇。窦虎拿出伪造的"卖身契"，阻挠父女团聚；垂涎于英娘美色的市令也从中作梗。这时，在此经商的伊努国挺身而出，不惜以重金为英娘赎身。在莫高窟内，女儿的舞姿，激发了神笔张的灵感，绘出了敦煌壁画中的衡世珍品--《反弹琵琶伎乐天》。 伊努思前来看望神笔张，发现洞窟内的壁画和彩塑，为之惊叹。当窟内充满欢乐气氛之时，市令要将英娘征为歌奴，企图霸占她。英娘惊闻噩耗，失声痛哭。神笔张忍痛把女儿托付给生死盟友伊努思，让她随商队逃往异国。市令诡计未逞，将神笔张囚禁莫高窟内，罚他戴镣作画。一日，河西节度使偕夫人来到莫高窟，看到《反弹琵琶伎乐天》的高超画艺，赞赏不已。当他见到身带镣铐的神笔张时，大为吃惊。他得知真情后，当即下令为他除去长镣，并赏给神笔张一支官制画笔。从此，神笔张获得了自由。 3年后，唐朝要召开27国交谊会。伊努思奉命作为波斯通商使节，就要率商队启程，英娘随商队返乡，欣喜万分。为感谢波斯亲人伊努思一家救护之恩，她将精心绣制的珍品《反弹琵琶伎乐天》赠给他们。神笔张得知27国交谊会即将召开，企望爱女能随商队返回。突然，他发现窦虎和市令正在密谋拦截波斯商队，他不顾危险，欲向商队报警，不幸被窦虎暗箭射中，倒在沙丘下。伊努思的商队遭到伏击，货物被抢劫一空，狠心的市令还要杀人灭口。危急关头，神笔张苏醒过来，爬上烽火台，点燃了烽火。市令与窦虎见已惊动四方，仓皇而逃。伊努思急步跑到神笔张身边，黯然泪下，英娘更是悲痛万分。 神笔张临终前把窦虎的暗箭交给英娘，嘱咐伊努思和女儿一定要剪除市令和窦虎这些奸官恶贼……英娘悲痛欲绝，发誓为父报仇。 27国交谊会隆重开幕。市令、窦虎把抢来的宝石琵琶献给河西节度使，以求升赏，这时，化装成老者的伊努思，向节度使请示献艺。英娘面蒙褐纱，跳起了盘上舞，获得了宾主的赞赏，舞罢，英娘扯开面纱，持箭直指仇人，并向节度使呈上暗箭，诉说使书被劫、父亲遭害的经过。节度使义愤填膺，下令拿下市令、窦虎，严惩了奸官恶贼，确保了中外通好。