高速公路上的猫源于一句谚语，用来形容注定不会长久的事情。乔凡尼（安东尼奥·阿尔巴内斯 Antonio Albanese 饰）是那种典型的知识分子，每天读书看报认真思考人生，始终相信人和人之间能够拥有真正的信任，互相融合。莫妮卡（宝拉·柯特莱西 Paola Cortellesi 饰）和乔凡尼恰恰相反，身为超市收银员的她每天都要应付不同肤色和不同人种的客人们，常常感到焦头烂额，对人和人之间的沟通感到非常悲观。　　上帝开了一个小小的玩笑，这两个八竿子打不到一起的人，他们的儿女却被牵上了红线走到了一起，得知了这一段恋情的两人由衷的希望它能像高速公路上的猫那样，尽早结束。

　　Mario Cavallaro is a Milanese who has just turned fifty. One day, Oba, a Senegalese sock vendor, appearing with his wares right in front of Mario’s hosiery shop. In order to put things back, Mario decides to kidnap Oba simply to send him back home. Oba consents to his “deportation” under the condition that Mario also accompany his sister, Dalida, back home. Too bad for Mario is that she is actual Oba’s fiancée – and that the two of them have decided to use this crazy man to secure a free trip home. But once the trip begins, sentiments mingle, will everything go back where it belongs?